HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Chiral NADH Models Derived from Optically Active Amino Alcohols

Georges Dupas, Vincent Levacher, Jean Bouguignon*, and Guy Quéguiner

*Laboratoire de Chimie Organique Fine et Heterocyclique de l'IRCOF, URA 1429 CNRS, INSA de Rouen, BP08, 76131 Mont-Saint-Aignan Cedex, France

Abstract

After a short description of the main characteristics of biomimetic NADH models, the choice of optically active amino alcohols as chiral auxiliaries is justified. The literature results in this field are then reviewed. The results obtained with 1,4-dihydropyridines, annelated models in the thiophene and pyrrole series are particularly discussed. The main factors responsible of a good enantioselectivity are emphasized and applied to the design of a highly enantioselective NADH model in the 1,6-naphtyridinone series.