Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Review | Special issue | Vol 47, No. 2, 1998, pp.1111-1133
Published online, 1st January, 1970
DOI: 10.3987/REV-97-SR(N)7
Bioactive Taxoids from Japanese Yew Taxus cuspidata and Taxol Biosynthesis

Jun'ichi Kobayashi* and Hideyuki Shigemori

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

Abstract

A series of new taxoids, named taxuspines A ~ H and J ~ Z (1 - 25), have been isolated together with 37 known taxoids (26 ~ 62) including taxol (42) from the Japanese yew Taxus cuspidata Sieb. et Zucc. These new taxoids possessed various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl2-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids as well as recent development of taxol biosynthesis.