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Review | Regular issue | Vol 48, No. 5, 1998, pp.1023-1043
Published online, 1st January, 1970
DOI: 10.3987/REV-98-496
High Pressure in Enzyme Catalyzed Organic Reactions

Nobuya Katagiri,* Masahiko Yamaguchi,* and Chikara Kaneko

*Faculty of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, sendai 980-8578, Japan

Abstract

Adenosine deaminase and lipases catalyzed hydrolysis under high pressure were described. The hydrolysis by both enzymes was facilitated by high pressure. this technique was used for the kinetical resolution of racemic highly modified nucleosides having biological activities.