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Communication | Special issue | Vol 7, No. 1, 1977, pp.73-75
Published online, 1st January, 1970
DOI: 10.3987/S-1977-01-0073
2-Substituted-amino-5-phenyl-1,3,4-oxadiazoles

Keith L. Turner and Stephen Turner*

*Reckitt & Colman Pharmaceutical Division, Dansom Lane, Hull, HU8 7DS, U.K.

Abstract

The sodium salt of 2-acetamido-5-phenyl-1,3,4-oxadiazole can be alkylated using activated bromides. Alkylation by an unactivated halide takes place intramolecularly. The N-substituted compounds and derivatives thus prepared were essentially inactive in a screening system for CNS activity.