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Communication | Special issue | Vol 7, No. 1, 1977, pp.123-129
Published online, 1st January, 1970
DOI: 10.3987/S-1977-01-0123
Synthesis of 11-Azaprostaglandin Analogs

Gerard P. Rozing, Henk de Kohnig,* and Henderikus O. Huisman

*Laboratory of Organic Chemistry, University of Amsterdam, Nieuwe Achtergracht 129,1018 WS Amsterdam, The Netherlands

Abstract

11-Deoxy-11-azaprostaglandin derivatives are obtained in eight steps, starting from methyl N-ethoxycarbonylglycinate and ethyl 4-tert-butoxycrotonate. The synthesis of an aza-analog of the “Corey-lactone” is described.