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Communication | Special issue | Vol 7, No. 2, 1977, pp.851-855
Published online, 1st January, 1970
DOI: 10.3987/S-1977-02-0851
Lipophilic (Hydrophobic) Cyclams with Long Alkyl Side-Chains

Iwao Tabushi* and Mariko Fujiyoshi

*Department of Synthetic Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyou-ku, Kyoto 606-8501, Japan

Abstract

One or two long alkyl chains were introduced either on carbon or nitrogen atom of cyclam (1,4,8,11-tetraazacyclotetradecane) via the direct alkylation or the condensation of the alkylmalonate with the tetramine followed by the borane reduction. Long alkyl substituted cyclams thus obtained are sparingly soluble in water and can extract heavy metal ions from aqueous solution to an organic phase.