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Communication | Special issue | Vol 7, No. 2, 1977, pp.885-890
Published online, 1st January, 1970
DOI: 10.3987/S-1977-02-0885
Facile Diketopiperazine Formation from Dipeptides Containing α-Aminoisobutyric Acid. Conformational Factors Influencing Cyclisation

Ramakrishnan Nagaraj and Padmanabhan Balaram*

*Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

Abstract

Diketopiperazines were formed in good yields on deprotection of N-protected dipeptide esters containing α-aminoisobutyric acid residues. Cyclisation is likely to be favoured by conformational constraints introduced by the gem dialkyl groups.