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Communication | Special issue | Vol 77, No. 1, 2009, pp.217-225
Published online, 18th August, 2008
DOI: 10.3987/COM-08-S(F)38
Synthetic Studies towards the Identification of Novel Capuramycin Analogs with Mycobactericidal Activity

Michio Kurosu* and Kai Li

*Immunology & Patholog, Department of Microbiology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523-1682, U.S.A.

Abstract

Expeditious syntheses of capuramycin, an effective MraY inhibitor in vivo, analogs are described. Synthetic schemes reported here are extremely useful for the generation of capuramycin analogs to identify minimum structure requirement to exhibit antimycobactericidal activity.