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Paper | Regular issue | Vol 78, No. 1, 2009, pp.59-70
Published online, 25th August, 2008
DOI: 10.3987/COM-08-11478
Synthesis of Azole Derivatives from 3-Phenylaminopropanhydrazide and Evaluation of Their Antimicrobial Efficacy

Ingrida Tumosiene, Kristina Kantminiene, Alvydas Pavilonis, Zaneta Mazeliene, and Zigmuntas J. Beresnevicius*

*Department of Organic Chemistry, Kaunas University of Technology, Radvilenu pl. 19, Kaunas LT-50254, Lithuania

Abstract

Novel pyrrole and pyrazole derivatives containing phenylaminopropanoyl moiety were synthesized from 3-phenylaminopropanohydrazide through its condensation with diketones. The intramolecular cyclization reaction of disubstituted semicarbazides and thiosemicarbazides was used to prepare new 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazole compounds. Some of the synthesized compounds were evaluated for in vitro antimicrobial activity.