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Paper | Regular issue | Vol 78, No. 1, 2009, pp.139-149
Published online, 22nd September, 2008
DOI: 10.3987/COM-08-11504
Reaction of Isatins with Active Methylene Compounds on Neutral Alumina: Formation of Knoevenagel Condensates and Other Interesting Products

Manas Chakrabarty,* Ratna Mukherjee, Shiho Arima, and Yoshihiro Harigaya

*Department of Chemistry, Bose Institute, 93/1, A. P. C. Road, Kolkata-700009, India

Abstract

Isatin and its N-methyl and 5-nitro derivatives underwent smooth reaction with a variety of acyclic and cyclic active methylene compounds on neutral alumina at room temperature to efficiently furnish Knoevenagel condensates in the majority of the cases and tandem Knoevenagel condensation-Michael addition products including spiro compounds in two cases.