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Communication | Special issue | Vol 77, No. 2, 2009, pp.759-765
Published online, 9th September, 2008
DOI: 10.3987/COM-08-S(F)65
Synthetic Studies of Mangostin Derivatives with an Inhibitory Activity on PDGF-Induced Human Aortic Smooth Cells Proliferation

Yuko Nishihama, Takahisa Ogamino, Wen Lei Shi, Byung-Yoon Cha, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Kiyotake Suenaga, Je-Tae Woo, and Shigeru Nishiyama*

*Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku Yokohama 223-8522, Japan

Abstract

The mangostin derivatives 3-10, were synthesized by halogenation, electrochemical oxidation, and mCPBA oxidation of α- and γ-mangostins (1, 2). Among them, the hydroxyl 9 and the benzopyran 10 derivatives produced by mCPBA, showed remarkable antiproliferative activities against human aortic smooth muscle cells (HASMC) induced by platelet-derived growth factor (PDGF).