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Communication | Special issue | Vol 77, No. 2, 2009, pp.779-785
Published online, 11th September, 2008
DOI: 10.3987/COM-08-S(F)68
Polymethylated γ-Carbolines with Potent Anti-bovine Viral Diarrhea Virus (BVDV) Activity

Hiroshi Aoyama,* Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba,* and Yuichi Hashimoto

*Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Abstract

Several anti-BVDV agents with a polymethylated γ-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.