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Review | Special issue | Vol 77, No. 2, 2009, pp.645-655
Published online, 18th September, 2008
DOI: 10.3987/REV-08-SR(F)4
Production of Unnatural Bioactive Glycosides Using Plant Secondary Product Glycosyltransferases

Sayaka Masada and Hajime Mizukami*

*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan

Abstract

Plant glycosyltransferases mediate transfer of a glycosyl residue from activated nucleotide sugars to lipophilic small molecules, thus affecting the solubility, stability and pharmacological activities of the compounds. Biotechnological application of the plant glycosyltransferases in glycoside synthesis has attracted attention recently. This review describes the in vivo and in vitro glycosylation of natural organic compounds using the glycosyltransferases, focusing on our current investigation for enzymatic synthesis of curcumin glycosides.