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Review | Regular issue | Vol 78, No. 7, 2009, pp.1627-1665
Published online, 2nd March, 2009
DOI: 10.3987/REV-08-639
Synthesis of Pyrimidines and Condensed Pyrimidines through Reactions of Nitriles with o-Aminocarbonyl Substrates under Acidic Conditions

Chamanlal Shishoo, Subramaniam Ananthan, Vishweshwar Bhadti, Giliyar Ullas, Mahesh Chhabria, Jitender Bariwal, Laxmi Venkatesh Gurachar Nargund, and Kishor Jain*

*Department of Pharmaceutical Chemistry, Sinhgad College of Pharmacy, S No 44/1, Vadgaon (BK), Sinhgad Road, Pune, 411 041, India

Abstract

The single pot facile reaction of a host of nitriles with a variety of o-aminocarbonyl substrates of benzene, thiophene, benzothiophene, pyridothiophene, furan, pyrrole, pyridopyrazole, naphthopyran etc., to form corresponding condensed pyrimidines functionalized at 2- and 4-positions has been reviewed and investigation into the reaction mechanisms and isolation of intermediates have been discussed. A new modification of this reaction under microwave condition has also been discussed. Further, a few applications of this novel reaction for the synthesis of API’s are also presented.