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Note | Regular issue | Vol 78, No. 1, 2009, pp.197-206
Published online, 4th September, 2008
DOI: 10.3987/COM-08-11510
A Novel and Efficient Approach to Pyrazolo[1,5-a]pyridine Derivatives via One-Pot Tandem Reaction

Yan-Qing Ge, Jiong Jia, Yan Li, Ling Yin, and Jianwu Wang*

*School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China

Abstract

An unusual intramolecular condensation of α,β-unsaturated esters with aldehydes was discovered and the pyrazolo[1,5-a]pyridine derivatives were conveniently synthesized by this novel tandem reaction under very mild conditions. The reaction mechanism was also proposed.