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Communication | Special issue | Vol 77, No. 2, 2009, pp.731-738
Published online, 11th November, 2008
DOI: 10.3987/COM-08-S(F)101
A Novel Δ-Thiolactone Scaffold by a Versatile Intramolecular Multicomponent Reaction

Stuti Srivastava, Barbara Beck, Eberhardt Herdtweck, Kareem Khoury, and Alexander Dömling*

*Department of Pharmaceutal Science and Chemistry, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.

Abstract

The three component reaction of α-aminoacids, mercaptoacetaldehyde and an isocyanide smoothly and stereoselectively yields the novel scaffold 1,2-disubstituted N-alkyl(aryl)-6-oxo thiomorpholine-3-carboxamide. In this communication we present our preliminary results on six compounds derived from this unprecedented reaction.