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Review | Special issue | Vol 77, No. 2, 2009, pp.679-729
Published online, 1st December, 2008
DOI: 10.3987/REV-08-SR(F)6
The Lycopodium Alkaloids

Yusuke Hirasawa, Jun'ichi Kobayashi, and Hiroshi Morita*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

Lycopodium alkaloids are unique heterocyclic alkaloids having C11N, C15N2, C16N, C16N2, C22N2, and C27N3 types from genus Lycopodium and have attracted great interest from biogenetic and biological points of view as well as providing challenging targets for total synthesis. This review covered the structure elucidation and biological activity of new Lycopodium alkaloids and total synthesis of some Lycopodium alkaloids reported in the literature from 2004 to July in 2008.