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Note | Regular issue | Vol 78, No. 2, 2009, pp.487-493
Published online, 16th October, 2008
DOI: 10.3987/COM-08-11516
An Efficient Protocol for the Friediänder Synthesis of Quinolines Using the Lewis Acidic Ionic Liquid Choline Chloride·2ZNCL2

Huey-Min Wang,* Rei-Sheu Hou, Hui-Ting Cheng, and Ling-Ching Chen*

*Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.

Abstract

Lewis acidic ionic liquid choline chlorideÅE2ZnCl2 is shown to be for the first time an excellent solvent and efficient catalyst for the synthesis of quinolines via Friedländer annulation under mild conditions.