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Paper | Regular issue | Vol 78, No. 1, 2009, pp.189-195
Published online, 22nd September, 2008
DOI: 10.3987/COM-08-11529
Synthesis of Related Substances of Cilostazol

Jin Zheng, Zheng Liu, Yiru Dai, Qingjie Zhao, and Jingshan Shen*

*Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zuchongzhi Rd., Zhangjiang Hi-Tech Park, Shanghai, 201203, China

Abstract

The impurities in API of cilostazol were detected by LC/MS during the process development. The structures of two impurities 6 and 7 and the related formation mechanisms were proposed. Synthesis of 6 and 7 was conducted for confirmation of the speculated structures.