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Note | Regular issue | Vol 78, No. 3, 2009, pp.757-761
Published online, 20th October, 2008
DOI: 10.3987/COM-08-11533
A Convenient Synthesis of 5-Arylidenethiazolidine-2,4-diones Catalyzed by Alkaline Ionic Liquid

Yi Hu, Tao Xie, Kai-Mei Fu, Hui Kang, Ping Wei, and He Huang*

*State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing Xin Mofan Road 5, Nanjing 210009, China


A series of 5-arylidenethiazolidine-2,4-diones was synthesized by the Knoevenagel condensation of thiazolidine-2,4-dione with aromatic aldehydes with alkaline ionic liquid 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) as dual solvent and catalyst. This method provides many advantages such as being environmentally benign, simple work-up, short reaction times, obtaining in good to excellent yields, and the reusability of ionic liquid.