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Note | Special issue | Vol 79, No. 1, 2009, pp.1073-1080
Published online, 9th October, 2008
DOI: 10.3987/COM-08-S(D)17
Design, Synthesis, and Biological Effect of (1-Oxo-1,2,3,4-Tetrahydro- β-Carbolin-9-yl)-acetic Acids as Inhibitor of Aldose Reductase 2

Naoki Toyooka,* Daisuke Takeda, Yuka Minoshima, Atsushi Kato, and Isao Adachi

*Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan

Abstract

Design and synthesis of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC50 = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).