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Paper | Special issue | Vol 79, No. 1, 2009, pp.647-658
Published online, 28th November, 2008
DOI: 10.3987/COM-08-S(D)31
Ruthenium Tetroxide Oxidation of N,N’-DiBoc-Hexahydropyridazines

Mamoru Kaname, Shigeyuki Yoshifuji, and Haruki Sashida*

*Faculty of Pharmaceutical Sciences, Hokuriku University, 3-Ho, Kanagawa machi, Kanazawa 920-1181, Japan


The ruthenium tetroxide (RuO4) oxidation of the 3-substituted N,N’-diBochexahydropyridazines gave the 6-oxohexahydropyridazines in good to high yields, whereas the oxidation of the unsubstituted ones also gave the 3,6-dioxo derivatives. The 3,6-cis-disubstituted pyridazines were essentially oxidized to give the 3-hydroxypyridazines; no oxidation of the trans-derivative occurred.