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Paper | Regular issue | Vol 78, No. 4, 2009, pp.923-936
Published online, 27th November, 2008
DOI: 10.3987/COM-08-11561
Novel and Efficient Synthesis of Pyrazolo[3,4-b]pyridin-6-ones or Their Hydrogenated Derivatives through One-Pot Reaction in Ionic Liquid

Xin-Ying Zhang,* Xiao-Yan Li, Xue-Sen Fan,* Xia Wang, Gui-Rong Qu, and Jian-Ji Wang

*College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, 453007, Henan, China

Abstract

Pyrazolo[3,4-b]pyridin-6-ones or their hydrogenated derivatives were obtained selectively and conveniently through one-pot reaction of aldehyde, ethyl cyanoacetate and 5-amino-3-methyl-1-phenylpyrazole in [bmim][BF4] with or without ferric chloride at different temperatures. Advantages of this novel method include high yield, mild conditions, simple procedure and good selectivity. In addition, the ionic liquid used can be easily recovered and effectively reused.