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Paper | Special issue | Vol 79, No. 1, 2009, pp.765-771
Published online, 31st October, 2008
DOI: 10.3987/COM-08-S(D)41
Naucleamide F, a New Monoterpene Indole Alkaloid from Nauclea latifolia

Yuka Kakuguchi, Haruaki Ishiyama, Takaaki Kubota, and Jun'ichi Kobayashi*

*Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


A new monoterpene indole alkaloid, naucleamide F (1), has been isolated from the bark and wood of Nauclea latifolia, and the structure and stereochemistry were elucidated on the basis of the spectral data. Naucleamide F (1) is a new monoterpene indole alkaloid consisting of a tetrahydro-β-carboline ring fused to a pyridone ring, and a 1,3,5-trioxepane ring fused to a dihydropyran ring and a glucose unit.