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Note | Special issue | Vol 79, No. 1, 2009, pp.1101-1105
Published online, 5th December, 2008
DOI: 10.3987/COM-08-S(D)62
Nupharic Acid, a New Sesquiterpene Alkaloid from Nuphar japonicum

Noriyuki Kogure, Akiko Nozoe, Mariko Kitajima, and Hiromitsu Takayama*

*Laboratory of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan


A new sesquiterpene alkaloid named nupharic acid (1) was isolated from the aerial part of Nuphar japonicum together with known alkaloids nupharidine (2) and deoxynupharidine (3). Alkaloid 1 is the first example of Nuphar alkaloids that lack the common furan moiety.