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Note | Special issue | Vol 79, No. 1, 2009, pp.1107-1112
Published online, 8th December, 2008
DOI: 10.3987/COM-08-S(D)65
Indole Alkaloids from the Leaves of Alstonia scholaris

Yusuke Hirasawa, Saori Miyama, Nobuo Kawahara, Yukihiro Goda, Abdul Rahman, Wiwied Ekasari, Aty Widyawaruyanti, Gunawan Indrayanto, Noor Cholies Zaini, and Hiroshi Morita*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A new indole alkaloid, akuammidine-N-oxide (1) was isolated from the leaves of Alstonia scholaris (Apocynaceae) together with akuammidine (2), and the structure was elucidated by NMR spectral analysis and chemical correlation. Akuammidine (2) showed a moderate antiplasmodial activity.