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Note | Special issue | Vol 79, No. 1, 2009, pp.1121-1126
Published online, 19th December, 2008
DOI: 10.3987/COM-08-S(D)72
Artopeden A, a New Antiplasmodial Isoprenylated Flavone from Artocarpus champeden

Tutik Sri Wahyuni, Wiwied Ekasari, Aty Widyawaruyanti, Yusuke Hirasawa, Hiroshi Morita,* and Noor Cholies Zaini*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A new isoprenylated flavone, artopeden A (1) was isolated from the barks of Artocarpus champeden (Moraceae), and the structure was elucidated by NMR spectral analysis. Artopeden A (1) showed a potent antiplasmodial activity with an IC50 of 0.045 μg/mL against Plasmodium falciparum 3D7.