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Paper | Special issue | Vol 77, No. 1, 2009, pp.273-277
Published online, 5th June, 2008
DOI: 10.3987/COM-08-S(F)7
Novel Process to 4,4-Dialkyl-1,4-dihydro-6-methoxy-3-phenylcinnolines via Grignard Reaction

Dongdong Chen, Chunhao Yang,* Yuyuan Xie, and Jian Ding

*State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai 201203, China

Abstract

4,4-Dialkyl-1,4-dihydro-6-methoxy-3-phenylcinnolines were obtained from 2-(5-methoxy-2-nitrophenyl)acetonitrile analogues and phenylmagnesium bromide by one step, and the possible mechanism was speculated.