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Paper | Regular issue | Vol 78, No. 4, 2009, pp.977-982
Published online, 3rd December, 2008
DOI: 10.3987/COM-08-11584
Synthesis of 4-Substituted 3,5-Dicyano-2,6-piperidinediones Using Lithium Nitride as a Convenient Source of Ammonia

Li qiang Wu,* Chunguang Yang, Liming Yang, and Lijuan Yang

*College of Pharmacy, Xinxiang Medical University, East of JinSui Road, XinXiang City, Henan Province, 453003, China

Abstract

A simple and efficient one-pot synthesis of 4-substituted-3,5-dicyano-2,6-piperidinediones was achieved in good yields via the three-component reaction of aldehyde or ketone, ethyl cyanoacetate, lithium nitride (Li3N) as a convenient source of ammonia in MeOH.