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Paper | Regular issue | Vol 78, No. 6, 2009, pp.1507-1522
Published online, 20th February, 2009
DOI: 10.3987/COM-09-11648
A Facile Access for Synthesis of Novel Isoquinoline-Based Heterocycles

Hamdi M. Hassaneen,* Tayseer A. Abdallah,* and Enas M. Awad

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt

Abstract

Hydrazonoyl halides 2, 7 and 12 react with alkyl 2-(3,4-dihydro-6,7-dimethoxy-2H-isoquinoline-1-ylidene)carboxylate 1 to give 4-(3,4-dihydro-6,7-dimethoxy-2H-isoquinoline-1-ylidene)-2,5-diaryl-2,4-dihydropyrazol-3-one 6, alkyl 2-arylazo-5,6-dihydro-8,9-dimethoxy-3-alkyl(or aryl)pyrrolo[2,1-a]isoquin-oline-1-carboxylate 10 and alkyl 2-(2-arylhydrazono)-2,3,5,6-tetrahydro-8,9-dimethoxy-3-oxopyrrolo[2,1-a]isoquinoline-1-carboxylate 15, respectively. The structures of the new compounds were elucidated on the basis of elemental analyses, spectral data and X-ray crystallographic analyses.