Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 78, No. 7, 2009, pp.1831-1836
Published online, 13th March, 2009
DOI: 10.3987/COM-09-11680
Antimalarial Activity of Cassiarin A from the Leaves of Cassia siamea

Wiwied Ekasari,* Aty Widyawaruyanti, Noor Cholies Zaini, Din Syafruddin, Toshio Honda, and Hiroshi Morita

*Departement of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Jl. Dharmawangsa Dalam Selatan, Surabaya 60286, Indonesia


The extracts and cassiarin A from the leaves of Cassia siamea showed promising antimalarial activities. The ethanol and chloroform extracts, alkaloid fraction, cassiarin A, and chloroquine as a positive control exhibited the inhibition against Plasmodium falciparum (IC50: 7.06, 2.41, 0.24, 0.005, and 0.006 μg/mL, respectively). The in vivo antimalarial activity was assessed using the 4-day suppressive test procedure. The ethanol, chloroform extracts, and alkaloid fraction were found to give an ED50 34.7, 19.59, and 0.47 mg/kg, respectively (p.o.). The ED50 values of cassiarin A and chloroquine were 0.17 and 0.21 mg/kg, respectively (i.p.). The result showed that cassiarin A deserved further investigation toward development of a promising antimalarial drug.