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Paper | Regular issue | Vol 78, No. 7, 2009, pp.1787-1798
Published online, 13th March, 2009
DOI: 10.3987/COM-09-11682
Synthesis and Antimicrobial Evaluation of New Pyrazole, Thiophene, Thiazole and 1,3,4-Thiadiazole Derivatives Incorporating Pyrimidine Ring

Ahmad M. Farag,* Nabila A. Kheder, and Yahia N. Mabkhot

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt

Abstract

The utility of 3-oxo-N-(pyrimid-2-yl)butanamide (1) in the synthesis of some new pyrazole, thiophene, thiazole, and 1,3,4-thiadiazole derivatives is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed moderate activity.