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Note | Regular issue | Vol 78, No. 7, 2009, pp.1837-1846
Published online, 23rd March, 2009
DOI: 10.3987/COM-09-11689
Effective Procedure for the Oxidative Cleavage of Olefins by OsO4-NaIO4

Hong Woo Lee,* Sung Kwon Kang, Choong Leol Yoo, and Seung Uk Lee

*New Drug Development Laboratories, Chemical Research Group, Chong Kun Dang Research Institute, Chonan P.O. Box 74, Chonan, 330-831, Korea

Abstract

Oxidative cleavage of olefins by OsO4-NaIO4 sometimes suffers from low yields due to the formation of side products. It is reported that the addition of pyrimidine can suppress the side reactions and dramatically improve the yield of this classic reaction.