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Paper | Regular issue | Vol 78, No. 9, 2009, pp.2217-2231
Published online, 23rd April, 2009
DOI: 10.3987/COM-09-11696
The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

Agnieszka Bogdanowicz,* Henryk Foks, Anna Kędzia, Ewa Kwapisz, Zofia Zwolska, and Ewa Augustynowicz-Kopeć

*Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. Hallera 107, 80-416 Gdańsk, Poland


Synthesis of 4-chloropicolinamidrazone derivatives starting from 4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity.