Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 78, No. 9, 2009, pp.2295-2314
Published online, 19th May, 2009
DOI: 10.3987/COM-09-11720
Trisubstituted Double Bond in the Cyclooctene Ring. Preparation Using the RCM Reaction

Reiko Mizutani, Takuo Miki, Katsuyuki Nakashima, Masakazu Sono, and Motoo Tori*

*Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro-machi, Tokushima, 770-8514, Japan

Abstract

Cyclization to eight-membered rings with a trisubstituted double bond was attempted using ring closing metathesis (RCM) reactions. Although simple substrates were not good candidates, the triene with a proper configuration cyclized to the cyclooctene with a tri-cycle (5-8-6 membered) in moderate yield. The formation of one-carbon smaller rings was also observed.