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Note | Regular issue | Vol 78, No. 10, 2009, pp.2571-2578
Published online, 12th June, 2009
DOI: 10.3987/COM-09-11753
■ 3′,4′-Dihydronorstephasubine, a New Bisbenzylisoquinoline from the Bark of Alseodaphne corneri

Mat Ropi Mukhtar,* Azeana Zahari, Mohd Azlan Nafiah, A. Hamid A. Hadi, Noel F. Thomas, Hiroko Arai, Hiroshi Morita, Marc Litaudon, and Khalijah Awang

*Department of Chemistry, Faculty of Science, University of Malaya, Pantai Valley, 50603 Kuala Lumpur, Malaysia

Abstract

A new bisbenzylisoquinoline, 3′,4′-dihydronorstephasubine (1) together with two known alkaloids, norstephasubine (2) and gyrolidine (3) were isolated from the stem bark of Alseodaphne corneri (Lauraceae). The 13C-NMR data for norstephasubine (2) and gyrolidine (3) were also reported. Structural elucidation of 1 was performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRMS. 3′,4′-Dihydronorstephasubine (1) and gyrolidine (3) showed moderate vasorelaxant effect on rat aorta.