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Note | Regular issue | Vol 78, No. 10, 2009, pp.2589-2594
Published online, 30th June, 2009
DOI: 10.3987/COM-09-11764
A Short Synthesis of Indolizidine (+)-209B from (3R,6S,8AS)-(-)-6-Methyl-3-phenyl-hexahydrooxazolo[3,2-a]pyridin-5-one

Dino Gnecco, Ana M. Lumbreras, Joel Luis Terán,* Alberto Galindo, Jorge R. Juárez, María L. Orea, Alejandro Castro, Raúl G. Enríquez, and William F. Reynolds

*Síntesis Orgánica, Benemérita Universidad Autónoma de Puebla, Complejo de Ciencias, Edif 103H, Ciudad Universitaria 72300, Mexico


The synthetic potential of enantiopure (3R,6S,8aS)-(-)-6-methyl-3- phenylhexahydrooxazolo[3,2-a]pyridin-5-one 2 is illustrated by a short synthesis of the 5,8-disubstituted indolizidine alkaloid (+)-209B.