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Note | Regular issue | Vol 78, No. 10, 2009, pp.2595-2600
Published online, 15th July, 2009
DOI: 10.3987/COM-09-11771
■ Curcuphenol Derivatives from the Gorgonian Echinomuricea Sp.

Hsu-Ming Chung, Tsong-Long Hwang, Wei-Hsien Wang,* Lee-Shing Fang, and Ping-Jyun Sung*

* , National Museum of Marine Biology and Aquarium, 2 Houwan Road, Checheng, Pingtung, Taiwan 944, Taiwan, R.O.C.

Abstract

Two sesquiterpenoid phenols, including a new natural product 1 [(7S,10R)-(+)-10,11-epoxycurcuphenol] and a known metabolite, (+)-curcuphenol (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of 1 and 2 were elucidated by interpretations of spectral data and by comparison of the related physical and spectral data with those of related metabolites. Compound 2 was found to show significant inhibitory effects on elastase release by human neutrophils.