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Paper | Regular issue | Vol 78, No. 11, 2009, pp.2787-2798
Published online, 7th September, 2009
DOI: 10.3987/COM-09-11787
A Convenient Synthesis of Novel Spiroisoindole γ-Halobutyrolactones via Halocyclization of γ-Ethylenic Acids

Mohamed M. Rammah, Mohamed Othman,* Kabula Ciamala, Michael Knorr, Carsten Strohmann, and Mohamed B. Rammah

*Laboratory of Organic Chemistry, URCOM, EA 3221, Faculty of Sciences and Techniques, University of Le Havre, 25 Rue Philippe Lebon, BP 540, F-76058 Le Havre Cedex, France


γ-Ethylenic carboxylic acids are cyclized to spiroisoindolone γ-halomethylbutyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding haloaspirobutyrolactones were isolated in high yields (57-95%).