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Note | Regular issue | Vol 78, No. 11, 2009, pp.2855-2861
Published online, 7th September, 2009
DOI: 10.3987/COM-09-11809
■ 13-Bromomonocillin I: A New WNT-5A Expression Inhibitor Produced by Pochonia chlamydosporia var. chlamydosporia

Hideki Shinonaga,* Noriyoshi Sakai, Yuriko Nozawa, Akiko Ikeda, Mari Aoki, and Akira Kawashima

*Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-Cho, Kita-ku, Saitama-city, Saitama 331-9530, Japan

Abstract

WNT-5A is a secretory glycoprotein related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, a new compound, 13-bromomonocillin I (1), was isolated from the fermentation broth of the fungus Pochonia chlamydosporia, cultured in NaBr-supplemented medium. 13-Bromomonocillin I (1) exhibited WNT-5A expression inhibitory activity with an IC50 value of 0.25 μM.