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Note | Regular issue | Vol 78, No. 12, 2009, pp.3081-3090
Published online, 11th September, 2009
DOI: 10.3987/COM-09-11818
Studies with 3-Oxoalkanonitriles: Synthesis and Reactivity of 3-Oxo-3-(1-methylindoloyl)propanenitrile

Haider Behbehani,* Hamada Mohamed Ibrahim, and Saad Makhseed

*Department of Chemistry, Faculty of Science, Kuwait University, Safat 13060, P.O. Box 5969, Kuwait

Abstract

N-Methylindole was acylated at C-3 with cyanoacetic acid and acetic anhydride to yield 3-cyanoacetyl-1-methylindole which could be utilized for synthesis of a diversity of indole derivatives with heterocyclic substituent.