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Paper | Regular issue | Vol 81, No. 4, 2010, pp.883-896
Published online, 10th February, 2010
DOI: 10.3987/COM-09-11882
N-Protected N2-Ethoxymethylenephenylglycine Hydrazides as Precursors of 1,3,4-Oxadiazole Derivatives

Agnieszka Kudelko* and Wojciech Zieliński

*Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Ul. Krzywoustego 4, PL-44100 Gliwice, Poland


New derivatives of N2-ethoxymethylene phenylglycine hydrazide protected at the amino group by acetyl and tert-butoxycarbonyl were synthesized with reactions of N-protected phenylglycine hydrazides and triethyl orthoesters. They underwent cyclization to the corresponding N-protected 2-aminomethyl-1,3,4-oxadiazoles in the presence of glacial acetic acid.