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Note | Regular issue | Vol 81, No. 4, 2010, pp.991-996
Published online, 10th February, 2010
DOI: 10.3987/COM-09-11899
12-epi-Fragilide G, a New Briarane-Type Diterpenoid from the Gorgonian Coral Ellisella robusta

Yu-Chia Chang, Tsong-Long Hwang, Sheng-Kai Huang, Li-Won Huang, Mei-Ru Lin, and Ping-Jyun Sung*

*National Museum of Marine Biology and Aquarium, 2 Houwan Road, Checheng, Pingtung, Taiwan 944, Taiwan, R.O.C.


A new chlorinated briarane-type diterpenoid, 12-epi-fragilide G (1), was isolated from the gorgonian coral Ellisella robusta. The structure of 1 was elucidated by the interpretations of spectral data analysis and this compound was found to possess an s-cis diene moiety in its structure. Briarane 1 displayed inhibitory effects on elastase release by human neutrophils.