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Paper | Regular issue | Vol 81, No. 5, 2010, pp.1183-1192
Published online, 1st March, 2010
DOI: 10.3987/COM-10-11910
Synthesis, Spectral Characterization and Antimicrobial Activity of Novel 5-[(Substituted Methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselena Phosphinan-2-ones

S. Subba Reddy, B. Satheesh Krishna, V. Koteswara Rao, and C. Naga Raju*

*Department of Chemistry, Sri Venkateswara University, Tirupati - 517502, India

Abstract

A series of novel 5-[(substituted) methyl]-5-oxo-1,3,2λ4,5λ5-dioxa selenaphosphinan-2-ones (4-17) were successfully synthesized from tris(bromomethyl)phosphine oxide (1) and sodium selenite (2) to form the intermediate(3) which on further treatment with various alcohols/ thiols/ phenols/ aminoacid esters afforded the title compounds (4-17) and their structures were established by multinuclear NMR (1H-, 13C- and 31P-) and mass spectral data. Their antimicrobial activity was evaluated and they exhibited promising antibacterial activity.