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Note | Special issue | Vol 82, No. 1, 2010, pp.881-886
Published online, 5th July, 2010
DOI: 10.3987/COM-10-S(E)48
Concise and Efficient Synthesis of 4-Hydroxy-2-pyrones from Pentane-2,4-diones

Masahiro Yoshida,* Hironobu Takai, Chika Mitsuhashi, and Kozo Shishido*

*Graduate School of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan


A concise method for the synthesis of 4-hydroxy-2-pyrones has been developed. Various 5-substituted 4-hydroxy-2-pyrones were efficiently prepared in two steps from 3-substituted pentane-2,4-diones.