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Note | Special issue | Vol 82, No. 1, 2010, pp.857-865
Published online, 7th July, 2010
DOI: 10.3987/COM-10-S(E)45
Simple Three Steps Synthesis of Potential Medicine for Metabolic Syndrome

Kazuhiro Adachi, Kyosuke Michigami, and Masahiko Hayashi*

*Department of Chemistry , Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

Efficient synthesis of the derivatives of JTP-426467 was achieved by three steps including 1) oxidative aromatization promoted by activated carbon, 2) hydrogenation, 3) amidation to afford the desired amide compounds in high yield.