Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 82, No. 1, 2010, pp.543-554
Published online, 8th June, 2010
DOI: 10.3987/COM-10-S(E)25
An Efficient Synthesis of Methyl Esters of Heterocyclic α,β-Didehydro-α-amino Acid Derivatives

Franc Požgan, Klavdija Lukman, and Marijan Kočevar*

*Department of Organic Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, P.O. Box 537, SI-1000 Ljubljana, Slovenia


N-Benzoyl-protected α,β-didehydro-α-amino acid (DDAA) derivatives containing a pyrazole or an isoxazole ring at the β-position were transformed with diazomethane into the corresponding methyl esters. Applying this method, the double C=C bond of the DDAA derivatives was not affected, thus selectively giving the corresponding esters in good-to-excellent yields.