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Paper | Special issue | Vol 82, No. 1, 2010, pp.431-439
Published online, 17th May, 2010
DOI: 10.3987/COM-10-S(E)14
Simple and Efficient One Pot Synthetic Protocol to Construct Morpholin-2-ones

Gorakh S. Yellol, Debendra K. Mohapatra, Mukund K. Gurjar,* and Chung-Ming Sun*

*Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300-10, Taiwan, R.O.C.


A new one pot synthetic method to construct 3-substituted morpholine-2-one derivatives is presented. Amino acids refluxed with 1,2-dibromoethane and potassium carbonate in acetonitrile followed by treatment with benzyl bromide in same pot furnished the 3-substituted N-benzyl-morpholine-2-ones in good yields. The simplicity of the reaction conditions and versatility of resulted scaffold to generate wide variety of molecules makes this method more attractive for synthetic organic chemists.