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Review | Special issue | Vol 82, No. 2, 2010, pp.981-1006
Published online, 24th August, 2010
DOI: 10.3987/REV-10-SR(E)4
Properties and Bioactivities of Peptoids Tagged with Heterocycles

Irene Izzo, Chiara De Cola, and Francesco De Riccardis*

*Department of Chemistry, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (SA), Italy

Abstract

N-substituted oligoglycines, also called “peptoids”, form a major class of pseudopeptides encompassing a wide range of structures and properties. Their inherent features make them useful in areas as diverse as medicinal chemistry, catalysis, and molecular recognition. In this review, the authors, with selected examples, show the wide range of properties of oligomeric peptoids tagged with heterocycles. It is also revealed how the imaginative structures created by synthetic chemists are exciting and varied, and, in which terms, their potential has just started to be addressed.