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Paper | Special issue | Vol 82, No. 1, 2010, pp.641-647
Published online, 18th June, 2010
DOI: 10.3987/COM-10-S(E)37
A Concise Total Synthesis of (±)-Centrolobine

Haruhiko Fuwa,* Kenkichi Noto, and Makoto Sasaki

*Tohoku University, 1-1, Tsutsumidori, Amamiya, Aoba-ku, Sendai, 981-8555, Japan


A concise total synthesis of (±)-centrolobine has been achieved in four linear steps from commercially available p-benzyloxybenzaldehyde via our developed domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization.